Isabel Rocha

Principal Investigator


  • Since  2019: Principal Investigator, Universidade Nova de Lisboa
  • 2011 - 2019: Assistant Professor, Universidade do Minho
  • 2006 - 2011: Invited Assistant Professor, Universidade do Minho
  • 2004 - 2006: Invited Lecturer, Universidade do Minho


  • 2003: PhD in Chemical and Biological Engineering, Universidade do Minho

Roles and Responsibilities

  • Since  2011: Member of the Scientific Steering Committee of Department, Department of Biological Engineering
  • 2010 - 2013: Program Director, Master Program in Bioinformatics - Biological Sciences
  • Since  2007: Member of Program Studies Steering Committee, PhD Program in Bioengineering
  • 2008 - 2008: APBio
  • Since  2013: Member of the Editorial Board of "Frontiers in Bioengineering and Biotechnology - Synthetic Biology"

Honors and Awards

  • 2011: Best Poster Award at 5th Annual Workshop on the Business-Government Interface: Systems and Synthetic Biology, Universidade do Minho, Braga. Title: Exploring the gap between dynamic and constraint-based models of metabolism.
  • Since 2019: Systems Biology and Metabolic Engineering
  • 2011 - 2019: UMinho Faculty member at Centre of Biological Engineering
  • 1998 - 2003: Model-based strategies for computer-aided operation of recombinant E. coli fermentation


Research Students

Recent Publications

Genome-wide sequencing and metabolic annotation of Pythium irregulare CBS 494.86: understanding Eicosapentaenoic acid production
  • BMC Biotechnology, 19(41), 2019
iDS372, a phenotypically reconciled model for the metabolism of Streptococcus pneumoniae strain R6
  • Frontiers in Microbiology, 10(1283), 2019
Comparison of pathway analysis and constraint-based methods for cell factory design
  • BMC Bioinformatics, 20(350), 2019
Turnover dependent phenotypic simulation: a quantitative constraint-based simulation method that accommodates all main strain design strategies
  • ACS Synthetic Biology, 8(5), 976-988, 2019
Mapping Salmonella typhimurium pathways using 13C Metabolic Flux Analysis
  • Metabolic Engineering, 52, 303-314, 2019
Identification and microbial production of the raspberry phenol salidroside that is active against Huntington's disease
  • Plant Physiology, 179(3), 969-985, 2019
Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl-CoA availability and increases plant polyphenol synthesis
  • Biotechnology and Bioengineering, 116(6), 1380-1391, 2019
Production of mannosylglycerate in Saccharomyces cerevisiae by metabolic engineering and bioprocess optimization
  • Microbial Cell Factories, 17(1), 178, 2018
Metabolic models and gene essentiality data reveal essential and conserved metabolism in prokaryotes
  • PLoS Computational Biology, 14(11), 1-23, 2018
Yeast chassis design for production of dicarboxylic acids
  • New Biotechnology, 44(Suppl.), S8, 2018
Heterologous production of resveratrol in bacterial hosts: current status and perspectives
  • Dudnik, Alexey; Almeida, A. Filipa; Andrade, Ricardo; Avila, Barbara; Bañados, Pilar; Barbay, Diane; Bassard, Jean-Etienne; Benkoulouche, Mounir; Bott, Michael; Braga, Adelaide; Breitel, Dario; Brennan, Rex; Bulteau, Laurent; Chanforan, Celine; Costa, Inês; Costa, Rafael S.; Doostmohammadi, Mahdi; Faria, Nuno; Feng, Chengyong; Fernandes, Armando; Ferreira, Patricia; Ferro, Roberto; Foito, Alexandre; Freitag, Sabine; Garcia, Gonçalo; Gaspar, Paula; Godinho-Pereira, Joana; Hamberger, Björn; Hartmann, András; Heider, Harald; Jardim, Carolina; Julien-Laferriere, Alice; Kallscheuer, Nicolai; Kerbe, Wolfgang; Kuipers, Oscar P.; Li, Shanshan; Love, Nicola; Marchetti-Spaccamela, Alberto; Marienhagen, Jan; Martin, Cathie; Mary, Arnaud; Mazurek, Vincent; Meinhart, Camillo; Sevillano, David Méndez; Menezes, Regina; Naesby, Michael; Nørholm, Morten H. H.; Okkels, Finn T.; Oliveira, Joana; Ottens, Marcel; Parrot, Delphine; Pei, Lei; Rocha, Isabel; Rosado-Ramos, Rita; Rousseau, Caroline; Sagot, Marie-France; dos Santos, Claudia Nunes; Schmidt, Markus; Shelenga, Tatiana; Shepherd, Louise; Silva, Rita M.; da Silva, Marcelo Henriques; Stahlhut, Steen Gustav; Simon, Olivier; Solopova, Ana; Sorokin, Artem; Stewart, Derek; Stougie, Leen; Su, Shang; Thole, Vera; Tikhonova, Olga; Trick, Martin; Vain, Philippe; Veríssimo, André; Vila-Santa, Ana; Vinga, Susana; Vogt, Michael; Wang, Liangsheng; Wang, Lijin; Wei, Wei; Youssef, Sandra; Neves, Ana Rute; Forster, Jochen
BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits
  • Phytochemistry Reviews, 17(2), 291-326, 2018
Methods for automated genome-scale metabolic model reconstruction
  • Biochemical Society Transactions, 46(4), 931-936, 2018
An adsorptive bioprocess for production and recovery of resveratrol with Corynebacterium glutamicum
  • Journal of Chemical Technology and Biotechnology, 93(6), 1661-1668, 2018
Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z
  • BMC Systems Biology, 12(61), 2018
Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test
  • Metabolomics, 14(4), 43-43, 2018
Quantitative physiology and elemental composition of Kluyveromyces lactis CBS 2359 during growth on glucose at different specific growth rates
  • Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 111(2), 183-195, 2018
Impact of the cultivation strategy on resveratrol production from glucose in engineered Corynebacterium glutamicum
  • Journal of Biotechnology, 265, 70-75, 2018
Genome-scale modeling of yeast: chronology, applications and critical perspectives
  • FEMS Yeast Research, 17(5), fox050, 2017
Development of a framework for metabolic pathway analysis-driven strain optimization methods
  • Interdisciplinary Sciences-Computational Life Sciences, 9(1), 46-55, 2017
Full List