Publications in International Journals / Series (Article (International))
Brazilian red propolis: extracts production, physicochemical characterization, and cytotoxicity profile for antitumor activity
- de Carvalho, Felipe Mendes de Andrade; Schneider, Jaderson Kleveston; de Jesus, Carla Viviane Freitas; de Andrade, Luciana Nalone; Amaral, Ricardo Guimarães; David, Jorge Maurício; Krause, Laíza Canielas; Severino, Patrícia; Soares, Cleide Mara Faria; Bastos, Elina Caramão; Padilha, Francine Ferreira; Gomes, Silvana Vieira Flores; Capasso, Raffaele; Santini, Antonello; Souto, Eliana B.; de Albuquerque-Júnior, Ricardo Luiz Cavalcanti
- Biomolecules, 10(5), 726, 2020
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Brazilian red propolis has been proposed as a new source of compounds with cytotoxic activity. Red propolis is a resinous material of vegetal origin, synthesized from the bees of the Appis mellifera family, with recognized biological properties. To obtain actives of low polarity and high cytotoxic profile from red propolis, in this work, we proposed a new solvent accelerated extraction method. A complete 23 factorial design was carried out to evaluate the influence of the independent variables or factors (e.g., temperature, number of cycles, and extraction time) on the dependent variable or re ...
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