NanoMaxiSafe

Project Title
Functionalized nanostructured delivery systems for food applications: strategies to maximize bioactive compounds’ bioavailability and their safety evaluation
Project Type
Nacional / Public
Funding Body
Funding Program
Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014
Reference
PTDC/AGR­TEC/5215/2014
Funding
  • CEB: 116 997,00
  • Total: 188 847,00
Start
01-07-2016
End
30-06-2019
Partnership
CEB; iBET

Principal Investigator

Team Members - CEB

Fellowship Members - CEB

Team Members - Non CEB

  • Catarina Duarte

Abstract

The incorporation of bioactive compounds in food products is often limited by their low bioavailability. Nanotechnology shows a huge potential for the development of novel delivery systems that allow the protection of valuable bioactive compounds during food processing and/or digestion and provide new functionalities (e.g. increase of bioavailability). Also, absorption enhancement technologies have been successfully used to increase membrane permeation of bioactive compounds. However, the application of these enabling technologies to food is hindered by very pertinent issues: preservation/maximization of the bioactive compounds’ bioactivity and safety, once inside human body. Therefore, the challenges addressed in this work are to develop optimized delivery systems for food applications, i.e. edible delivery systems that maximize the bioactive compounds’ bioavailability, and to evaluate their safety. This will be achieved using an innovative approach: testing different absorption enhancers and nanostructures’ formulations, evaluating their digestion/absorption behaviour and monitoring their inflammatory responses, by combining a dynamic gastrointestinal system and in vitro cell models (Caco-2/HT29-MTX co-culture and immune systems).