Helicophage

Project Title
Development of an engineered-phage cocktail to combat Helicobacter pylori infections and prevent gastric cancer
Project Type
Nacional / Public
Funding Body
Funding Program
02/SAICT/2017 - Projetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT)
Reference
POCI-01-0145-FEDER-029182
Funding
  • CEB: 181 022,00
  • Total: 235 397,00
Start
01-10-2018
End
30-09-2021
Partnership
UMinho, UPorto, IPATIMUP, INSA

Principal Investigator

Abstract

Helicobacter pylori colonizes the human gastric mucosa being associated with the development of several gastric diseases, namely distal gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. The World Health Organization designate this organism a class I carcinogen and a high risk pathogen due to the recent increase of antibiotic resistance. The use of bacteriophages as alternatives to antibiotics have been widely used for different types of infection. In this project we aim at developing a bacteriophage cocktail that acts specifically against this microorganism. For that, we will isolate and characterize new H. pylori strains that will be used as hosts to isolate new phages. Then we will develop a cocktail composed of genetically-modified phages to make them safe (no toxins or temperate-origin genes) and efficient (survival to harsh gastric conditions). The dynamic response, efficacy and safety of the developed product will be characterized in vivo in a rodent model.