Publications in International Journals / Series (Article (International))

The activity of LE10 peptide on biological membranes using molecular dynamics, in vitro and in vivo studies

  • Colloids and Surfaces B- Biointerfaces, 106, 240-247, 2013

Publisher: Elsevier

Abstract

Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) are generally defined as small cationic peptides with the ability to interact with lipidic membranes, in a process driven by electrostatic and hydrophobic processes. The interaction with CPPs is known to lead to its translocation across the membrane, while with AMPs lead to membrane damage. Here we present one synthetic anionic peptide, LE10 (LELELELELELELELELELE), which strongly interacts with model membranes, showing properties of CPPs (translocation through lipidic membranes on a mechanism usually described for cationic CPP ...

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