Publications in International Journals / Series (Article (International))

Antibacterial activity of phenyl isothiocyanate on Escherichia coli and Staphylococcus aureus

  • Abreu, A.C.; Borges, A.; Simões, L.C.; Saavedra, M.J.; Simões, M.
  • Medicinal Chemistry, 9(5), 756-761, 2013

Publisher: Bentham Science Publishers


The present study has been aimed to assess the antibacterial effects of the glucosinolate hydrolysis product phenyl isothiocyanate (PITC) against Escherichia coli and Staphylococcus aureus. Aspects on the antibacterial mode of action of PITC have also been characterized, such as the changes on surface physicochemical characteristics and membrane damage. The minimum inhibitory concentration of PITC was 1000 􀀁g/mL, for both bacteria. The antimicrobial potential of PITC was compared with selected antibiotics (ciprofloxacin, erythromycin, streptomycin, tetracycline and spectinomycin),that reporte ...

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ISI Web of Science® Citations: 15


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