Publications in International Journals / Series (Article (International))

Gene silencing by siRNA nanoparticles synthesized via sonochemical method

  • Journal of Nanomedicine & Nanotechnology, 5(3), 1-5, 2014

Publisher: OMICS Group Inc.,

Abstract

The knowledge that small RNAs can affect gene expression has had a tremendous impact on basic and applied research, and gene silencing is currently one of the most promising new approaches for disease therapy. However, RNAs cannot easily penetrate cell membranes, therefore RNA delivery become one of the major challenges for gene silencing technology. In the current paper we discuss a general approach for converting siRNA molecules into a dense siRNA nanoparticles using environmentally friendly sonochemical method. The RNA nanoparticulation enhance its gene-silencing activity in vascular bovine ...

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