Publications in International Journals / Series (Article (International))

Functionalized protein nanoemulsions by incorporation of chemically modified BSA

  • RSC Advances, 5(7), 4976-4983, 2015

Publisher: The Royal Society of Chemistry

Abstract

The incorporation of bioactive compounds in stealth nanoparticles or nanoemulsions enhances their half-life in systemic circulation and can overcome the problems associated with the free drug. Bovine serum albumin (BSA)–drug conjugates were produced with either methotrexate (MTX), a potent anticancer agent, or vancomycin (VCM), a potent antibiotic. Those conjugates were used to produce functionalized BSA nanoemulsions in a formulation composed of an aqueous phase and an organic phase. BSA–folic acid (FA) conjugates were also produced allowing specific folate receptor (FR) mediated targeting of ...

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ISI Web of Science® Citations: 12

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