Publications in International Journals / Series (Article (International))

Peptide anchor for folate-targeted liposomal delivery

  • Biomacromolecules, 16(9), 2904-2910, 2015

Publisher: American Chemical Society

Abstract

Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. Here, we report an innovative strategy for targeted liposome delivery that uses a hydrophobic fragment of surfactant protein D linked to folate. Our proposed spacer is a small 4 amino acid residue linker. The peptide conjugate inserts deeply into the lipid bilayer without affecting ...

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ISI Web of Science® Citations: 12

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