Publications in International Journals / Series (Article (International))

Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice

  • Nogueira, Eugénia; Lager, Franck; Le Roux, Delphine; Nogueira, Patrícia; Freitas, Jaime; Charvet, Celine; Renault, Gilles; Loureiro, Ana; Almeida, Catarina R.; Ohradanova-Repic, Anna; Machacek, Christian; Bernardes, Gonçalo J.L.; Moreira, Alexandra; Stockinger, Hannes; Burnet, Michael; Carmo, Alexandre M.; Gomes, A.C.; Preto, A.; Bismuth, Georges; Cavaco-Paulo, Artur
  • Journal of Biomedical Nanotechnology, 11(12), 2243-2252, 2015

Publisher: American Scientific Publishers

Abstract

Methotrexate is the first line of treatment of rheumatoid arthritis. Since many patients become unresponsive to methotrexate treatment, only very expensive biological therapies are effective and increased methotrexate tolerance strategies need to be identified. Here we propose the encapsulation of methotrexate in a new liposomal formulation using a hydrophobic fragment of surfactant protein conjugated to a linker and folate to enhance their tolerance and efficacy. In this study we aim to evaluate the efficiency of this system to treat rheumatoid arthritis, by targeting folate receptor  presen ...

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