Publications in International Journals / Series (Article (International))

In vivo confocal Raman spectroscopy and molecular dynamics analysis of penetration of retinyl acetate into stratum corneum

  • SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 174, 279-285, 2017

Publisher: Elsevier

Abstract

Objective The purpose of this study is to elucidate the behavior of retinyl acetate in penetrating human skin without the presence of enhancers by using confocal Raman spectroscopy and molecular dynamics simulation. Methods In this study, in vivo confocal Raman spectroscopy was combined with molecular dynamics simulation to investigate the transdermal permeation of the aqueous suspension of retinyl acetate. Results Permeation was measured after 30 min, and retinyl acetate was found up to 20 μm deep inside the stratum corneum. The delivery of retinyl acetate inside a skin membrane model was stu ...

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