Publications in International Journals / Series (Article (International))

Targetability of hyaluronic acid nanogel to cancer cells: In vitro and in vivo studies

  • European Journal of Pharmaceutical Sciences, 104, 102-113, 2017

Publisher: Elsevier

Abstract

We have, in previous work developed, characterized and evaluated the biocompatibility of an engineered hyaluronic acid nanogel. Here we assess the targetability of a hyaluronic acid nanogel towards CD44 overexpressing cells, in vitro and in vivo. Results obtained by flow cytometry and confocal fluorescence microscopy shows that nanogel is greatly internalized by non-small cancer lung cells (A549 cells), that overexpress CD44 receptors. The biodistribution and tumor targetability of the nanogel labelled with a near-infrared (NIR) probe were performed, in mice, through a non-invasive imaging sys ...

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