MSc Dissertations

Molecular mechanisms underlying the anticancer activity of lactoferrin in highly metastatic cancer cell lines

  • Mestrado em Genética Molecular (ECUM), 2017

Abstract

Cancer is currently one the most lethal disease worldwide and metastases remain the main cause of cancer-associated mortality, which reinforces the importance of developing more targeted and efficient cancer therapies. In this sense, lactoferrin (Lf) has emerged as a safe and effective agent in cancer therapy. Lf is a natural iron-binding protein derived from milk that is present in many tissues and biological fluids. Interestingly, it was found that Lf displays anticancer and anti-metastatic activities against several cancer cell lines. However, Lf cellular targets implicated in its mechanism ...

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