Conference Proceedings (Abstracts in Conference Proceedings)

Substrate inhibition of uracil phosphoribosyltransferase (UPRT) in distinct microbial species and its implications in the phenotype of uracil auxotrophs

  • Microbiotec'17 - Congress of Microbiology and Biotechnology 2017. No. P-307, Porto, Portugal, Dec 7-9, 437-437, 2017

Abstract

Background Unlike the established practice, the supply of exogenous uracil cannot fully rescue uracil auxotrophy in Ura- mutants of some species of industrial and/or medical significance (e.g. Ashbya gossypii, Candida guilliermondii, C. albicans, Leishmania donovani), which require uridine for proper growth [1-4]. Here we reveal the molecular mechanism underlying this phenotype in A. gossypii and disclose common features with protozoan parasites and other flavinogenic/pathogenic fungi. Method Analysis of the A. gossypii Agura3 (Ura- mutant) radial growth on minimal medium containing distinct p ...

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