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Photonic modulation of EGFR halts receptor activation and cancer cell migration

  • Botelho, Cláudia M.; Gonçalves, O.; Marques, R.; Thiagarajan, V.; Vorum, H.; Gomes, A.; Petersen-Neves, T.
  • Journal of Biophotonics, (In Press), 2018

Publisher: Wiley-Blackwell

Abstract

Epidermal Growth Factor Receptor (EGFR) plays a key role in regulating cell survival, proliferation and migration, and its overexpression and activation has been correlated with cancer progression. Cancer therapies targeting EGFR have been applied in the clinic with some success. We show, by confocal microscopy analysis, that illumination of adenocarcinomic human alveolar basal epithelial cells (Human A549 – EGFR biosensor cell line) with 280 nm at irradiance levels up to 20 times weaker than the UVB solar output for short periods of time (15-45 min) prevents EGF-mediated activation of EGFR lo ...

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