Publications in International Journals / Series (Article (International))

Portrait of matrix gene expression in Candida glabrata biofilms with stress induced by different drugs

  • Genes, 9(4), 205, 2018

Publisher: Multidisciplinary Digital Publishing Institute (MDPI)

Abstract

(1) Background: Candida glabrata is one of the most significant Candida species associated with severe cases of candidiasis. Biofilm formation is an important feature, closely associated with antifungal resistance, involving alterations of gene expression or mutations, which can result in the failure of antifungal treatments. Hence, the main goal of this work was to evaluate the role of a set of genes, associated with matrix production, in the resistance of C. glabrata biofilms to antifungal drugs. (2) Methods: the determination of the expression of BGL2, XOG1, FKS1, FKS2, GAS2, KNH1, UGP1, an ...

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