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Protein crystallization in a droplet-based microfluidic device: Hydrodynamic analysis and study of the phase behaviour

  • Chemical Engineering Science, 191, 232-244, 2018

Publisher: Elsevier

Abstract

This work reports a cheap and easy-to-use droplet-based microfluidic platform for the study of protein crystallization, offering the possibility to characterize the protein phase behaviour, and the effect of volumetric and interfacial phenomena on the crystallization mechanism. We conducted a parametric study supported by comparison with literature data, to quantify the influence of the droplet volume on the thermodynamic (solubility data) and kinetic (metastability data) parameters, using lysozyme as a model protein. Experiments were performed in a tubular microreactor at low Capillary number ...

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