Publications in International Journals / Series (Review (International))

A review of dynamic modeling approaches and their application in computational strain optimization for metabolic engineering

  • Frontiers in Microbiology, 9, 1690-1690, 2018

Publisher: Frontiers Media S.A.

Abstract

Mathematical modeling is a key process to describe the behavior of biological networks. One of the most difficult challenges is to build models that allow quantitative predictions of the cells' states along time. Recently, this issue started to be tackled through novel in silico approaches, such as the reconstruction of dynamic models, the use of phenotype prediction methods, and pathway design via efficient strain optimization algorithms. The use of dynamic models, which include detailed kinetic information of the biological systems, potentially increases the scope of the applications and the ...

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