MSc Dissertations

Exploring the molecular mechanisms involved in macrophage’s response to the antimicrobial peptide LLKKK18

  • Mestrado em Genética Molecular (ECUM), 2018

Abstract

Tuberculosis (TB) is an infectious disease that represents a serious health problem worldwide. This condition is caused mainly by Mycobacterium tuberculosis, a bacterium that can manage to evade the immune response, surviving inside macrophages. Globally, TB incidence, prevalence and mortality are decreasing, however, drug resistance to the current treatments makes TB eradication progressively challenging. In this perspective, antimicrobial peptides, molecules used by the innate immune system to combat invading pathogens including mycobacteria, are promising candidates for TB treatment. A cath ...

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