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In silico predictions for fucoxanthin production by the diatom Phaeodactylum tricornutum

  • Bauer, Claudia M.; Vilaça, Paulo; Ramlov, Fernanda; de Oliveira, Eva Regina; Cabral, Débora Q.; Schmitz, Caroline; Corrêa, Rafaela Gordo; Rocha, Miguel; Maraschin, Marcelo
  • Advances in Intelligent Systems and Computing, 803 (PACBB 2018), 139-148, 2019

Publisher: Springer

Abstract

Diatoms and brown seaweeds are the main producers of fucoxanthin, an oxy-carotenoid with important biological functions related to its antioxidative properties. The diatom Phaeodactylum tricornutum appears in this scenario as a good source for fucoxanthin production. Its whole genome sequence was published in 2008, and some genome-scale metabolic models are currently available. This work intends to make use of the two most recent genome-scale metabolic models published to predict ways to increase fucoxanthin production, using constraint-based modeling and flux balance analysis. One of the mode ...

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