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Quantitative assessment of DNA damage in the industrial ethanol production strain Saccharomyces cerevisiae PE-2

  • FEMS Yeast Research, 18(8), foy101, 2018

Publisher: Oxford University Press

Abstract

Lignocellulosic hydrolysates remain one of the most abundantly used substrates for the sustainable production of second generation fuels and chemicals with Saccharomyces cerevisiae. Nevertheless, fermentation inhibitors such as acetic acid, furfural and hydroxymethylfurfural are formed during the process and can lead to slow or stuck fermentations and/or act as genotoxic agents leading to production strain genetic instability. We have developed a novel dominant deletion (DEL) cassette assay for quantification of DNA damage in both wild-type and industrial yeast strains. Using this assay, the e ...

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