Publications in International Journals / Series (Article (International))

The MNN2 gene knockout modulates the antifungal resistance of biofilms of Candida glabrata

  • Biomolecules, 8(4), 130, 2018

Publisher: Multidisciplinary Digital Publishing Institute (MDPI)


Candida glabrata biofilms are recognized to have high resistance to antifungals. In order to understand the effect of mannans in the resistance profile of C. glabrata mature biofilms, C. glabrata Δmnn2 was evaluated. Biofilm cell walls were analysed by confocal laser scanning microscopy (CLSM) and their susceptibility was assessed for fluconazole, amphotericin B, caspofungin, and micafungin. Crystal violet and Alcian Blue methods were performed to quantify the biomass and the mannans concentration in the biofilm cells and matrices, respectively. The concentration of β-1,3 glucans was also meas ...

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