Publications in International Journals / Series (Article (International))

Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells

  • Souto, Eliana B.; Slavomira Doktorovova; Joana R. Campos; Paula Martins-Lopes; Amélia M. Silva
  • European Journal of Pharmaceutical Sciences, 128, 27-35, 2019

Publisher: Elsevier

Abstract

CAB51, a compact antibody against human epithelial growth receptor 2 (HER2, ErbB2), has been linked to cationic Solid Lipid Nanoparticles (SLN) via streptavidin-biotin interaction and their targeting potential evaluated against breast cancer cells. The amount of streptavidin and biotinylated antibody was optimised by monitoring the mean complex size (intensity weighed average diameter), polydispersity index and immediate stability in phosphate buffer saline (PBS). The effect on MCF-7 and BT-474 cells was evaluated at concentrations of 0.01?mg/mL and 0.1?mg/mL (counted as solid lipid). Streptav ...

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