Publications in International Journals / Series (Article (International))

Design of a chromogenic substrate for elastase based on split GFP system – proof of concept for colour switch sensors

  • Biotechnology Reports, 22(e00324), 2019

Publisher: Elsevier BV


Recent studies have demonstrated that human neutrophil elastase (HNE) can be used as marker for inflammation/infection of chronic wounds since it was found to be present in high concentration in exudate collected from chronic wounds. Biosensors used in wound care benefit from a chromogenic signalling due to the readiness of signal interpretation, but the most common use faint yellow chromogenic molecules such as p-nitroaniline (pNa). In addition, if to be converted into smart dressings, the colour of the detection system should not be masked by the exudate’s colour. In this work, we designed a ...

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