Publications in International Journals / Series (Article (International))

Design of a chromogenic substrate for elastase based on split GFP system – proof of concept for colour switch sensors

  • Biotechnology Reports, 22(e00324), 2019

Publisher: Elsevier BV

Abstract

Recent studies have demonstrated that human neutrophil elastase (HNE) can be used as marker for inflammation/infection of chronic wounds since it was found to be present in high concentration in exudate collected from chronic wounds. Biosensors used in wound care benefit from a chromogenic signalling due to the readiness of signal interpretation, but the most common use faint yellow chromogenic molecules such as p-nitroaniline (pNa). In addition, if to be converted into smart dressings, the colour of the detection system should not be masked by the exudate’s colour. In this work, we designed a ...

CEB Authors

Groups

Citations

ISI Web of Science® Citations: 0

0

Share Content