Publications in International Journals / Series (Article (International))

Quantification of drugs encapsulated in liposomes by 1H NMR

  • Colloids and Surfaces B- Biointerfaces, 179, 414-420, 2019

Publisher: Elsevier

Abstract

Liposomes are one of the most important and extensively studied drug delivery system due to their ability to encapsulate different kinds of drugs. Exploiting the advantages of 1H Nuclear Magnetic Resonance (NMR) spectrometry, we established a rapid and easy method for quantification of drugs encapsulated in liposomes. An internal standard, pyridine, was used for quantitative determination of drug concentration. Two different drugs were involved in this work, one hydrophilic, methotrexate disodium salt, and another hydrophobic, tamoxifen. The specificity and selectivity of the suggested method ...

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