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Troppo - A Python framework for the reconstruction of context-specific metabolic models

  • Advances in Intelligent Systems and Computing, 1005 (PACBB 2019), 146-153, 2019

Publisher: Springer

Abstract

The surge in high-throughput technology availability for molecular biology has enabled the development of powerful predictive tools for use in many applications, including (but not limited to) the diagnosis and treatment of human diseases such as cancer. Genome-scale metabolic models have shown some promise in clearing a path towards precise and personalized medicine, although some challenges still persist. The integration of omics data and subsequent creation of context-specific models for specific cells/tissues still poses a significant hurdle, and most current tools for this purpose have be ...

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