Bioprocess and Bionanotechnology
Main Topics of the Research Team
Development of formulations of asparaginases for leukaemia tailoring:
- Low immune reactions.
- Low ammonia production.
Development of detection methods for assessment in chronic wounds
Low water processes using soluble or immobilized esterase enzymes for production of:
- Cellulose derivatives with fatty acids for textile applications.
- Production of active components where a fatty acid is replaced by carboxylic drug in triacyl glycerol.
Enzyme polymerization of phenolics
Laccase enzymes in nature have the function of breakdown lignin compounds into small aromatic compounds. The contact of these phenolic with laccase further oxidase them into a network of polyphenolic compounds.
Formulation of enzymes for industrial applications
Use of laccases/esterases/protease enzymes for modification of textiles. Work mainly done at College of Textiles, University Jiangnan, China.
Focus on development of peptides using microarray technology for controlling hair: shape, strength and humidity properties. The genetics basis of hair color and hair study is studied as well with collaboration with the department of biology.
Molecular dynamics Tools
For transdermal and hair delivery of active components.
For protein stability, interactions and docking and other tools.
Fine and coarse grain simulations are used depending on the complexity of the systems used.
Nano and micro-formulations
Micro- and nano-scale systems have emerged as important tools for developing useful drug delivery systems. Biomacromolecules are exploited for this purpose such as proteins, polypeptides, nucleic acids, polysaccharides, co-polymers and phospholipids as potential building blocks for novel drug delivery systems. The research focus on the group it is mechanisms of formation of micro- and nano-scale capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. The focus of the group is the development of liposomal and emulsions vehicles for intravenous, intestinal and skin applications.