BFACTORY People

Tatiana Q. Aguiar

Junior Researcher

Research Line: Industrial Biotechnology and Bioengineering
Research Group: B.Factory
Lab.: Molecular Biotechnology Laboratory
253 601 989 (office) / 253 601 973 (lab)
tatiana.aguiar@deb.uminho.pt
http://ceb.uminho.pt/People/Profile/tatianaaguiar

Career

Since 2018: Junior Researcher, Universidade do Minho

Qualifications

2013: PhD Program in Bioengineering, Universidade do Minho

Since 2018: Metabolic engineering tools for Ashbya gossypii.
2015 - 2018: Development of novel metabolic engineering tools for Ashbya gossypii
2013 - 2015: GlycoCBMs - Fiber modification using recombinant glycosylated cellulose-binding modules
2007 - 2013: Understanding the biotechnological potential of Ashbya gossypii

Projects

Research Students

Ana Isabel da Costa Freitas - Faculty Researcher at CEB
Marlene Isabel Cerqueira Baptista - Master Student
Rui Miguel Correia da Silva - PhD Student

Recent Publications

1	Silva, Rui; Aguiar, Tatiana Q.; Coelho, Eduardo; Jiménez, Alberto; Revuelta, José Luis; Domingues, Lucília Metabolic engineering of Ashbya gossypii for deciphering the de novo biosynthesis of γ-lactones Microbial Cell Factories, 18(62), 2019
2	Silva, Rui; Aguiar, Tatiana Q.; Oliveira, Carla; Domingues, Lucília Physiological characterization of a pyrimidine auxotroph exposes link between uracil phosphoribosyltransferase regulation and riboflavin production in Ashbya gossypii New Biotechnology, 50, 1-8, 2019
3	Silva, Rui; Aguiar, Tatiana Q.; Oliveira, Rui; Domingues, Lucília Light exposure during growth increases riboflavin production, reactive oxygen species accumulation and DNA damage in Ashbya gossypii riboflavin-overproducing strains FEMS Yeast Research, 19(1), foy114, 2019
4	Díaz-Fernández, David; Aguiar, Tatiana Q.; Martín, Victoria Isabel; Romaní, Aloia; Silva, Rui; Domingues, Lucília; Revuelta, José Luis; Jiménez, Alberto Microbial lipids from industrial wastes using xylose-utilizing Ashbya gossypii strains Bioresource Technology, No. 122054, (In Press), 2019
5	Aguiar, Tatiana Q.; Silva, Rui; Domingues, Lucília New biotechnological applications for Ashbya gossypii: Challenges and perspectives Bioengineered, 8(4), 309-315, 2017
6	Aguiar, Tatiana Q.; Silva, Rui; Domingues, Lucília Ashbya gossypii beyond industrial riboflavin production: a historical perspective and emerging biotechnological applications Biotechnology Advances, 33(8), 1774-1786, 2015
7	Oliveira, Carla; Sepúlveda, Goreti; Aguiar, Tatiana Q.; Gama, F. Miguel; Domingues, L. Modification of paper properties using carbohydrate-binding module 3 from the Clostridium thermocellum CipA scaffolding protein produced in Pichia pastoris: elucidation of the glycosylation effect Cellulose, 22(4), 2755-2765, 2015
8	Silva, R.; Aguiar, T.Q.; Domingues, L. Blockage of the pyrimidine biosynthetic pathway affects riboflavin production in Ashbya gossypii Journal of Biotechnology, 193, 37-40, 2015
9	Cunha, J.T.; Aguiar, Tatiana Q.; Romaní, A.; Oliveira, Carla; Domingues, L. Contribution of PRS3, RPB4 and ZWF1 to the resistance of industrial Saccharomyces cerevisiae CCUG53310 and PE-2 strains to lignocellulosic hydrolysate-derived inhibitors Bioresource Technology, 191, 7-16, 2015
10	Aguiar, Tatiana Q.; Ribeiro, O.; Arvas, M.; Wiebe, M.G.; Penttilä, M.; Domingues, Lucília Investigation of protein secretion and secretion stress in Ashbya gossypii BMC Genomics, 15(1137), 2014
11	Aguiar, T.Q.; Dinis, C.; Magalhães, F.; Oliveira, C.M.; Wiebe, M. G.; Penttilä, M.; Domingues, L. Molecular and functional characterization of an invertase secreted by Ashbya gossypii Molecular Biotechnology, 56(6), 524-534, 2014
12	Aguiar, Tatiana Q.; Dinis, Cláudia; Domingues, Lucília Cre-loxP-based system for removal and reuse of selection markers in Ashbya gossypii targeted engineering Fungal Genetics and Biology, 68, 1-8, 2014
13	Gomes, D.G.; Aguiar, T.Q.; Dias, O.; Ferreira, E.C.; Domingues, L.; Rocha, I. Genome-wide metabolic re-annotation of Ashbya gossypii: new insights into its metabolism through a comparative analysis with Saccharomyces cerevisiae and Kluyveromyces lactis BMC Genomics, 15(810), 2014
14	Magalhães, F.; Aguiar, T.Q.; Oliveira, C.M.; Domingues, L. High-level expression of Aspergillus niger β-galactosidase in Ashbya gossypii Biotechnology Progress, 30(2), 261-268, 2014
15	Aguiar, T.Q.; Maaheimo, H.; Heiskanen, A.; Wiebe, M.G.; Penttilä, M.; Domingues, L. Characterization of the Ashbya gossypii secreted N-glycome and genomic insights into its N-glycosylation pathway Carbohydrate Research, 381, 19-27, 2013
16	Ribeiro, O.; Magalhães, F.; Aguiar, Tatiana Q.; Wiebe, M. G.; Penttilä, M.; Domingues, Lucília Random and direct mutagenesis to enhance protein secretion in Ashbya gossypii Bioengineered, 4(5), 13-22, 2013
17	Ferreira, M.; Aguiar, T.Q.; Vilarinho, L. Cadeia respiratória mitocondrial: Aspectos clínicos, bioquímicos, enzimáticos e moleculares associados ao défice do complexo I Arquivos de Medicina, 22(2-3), 49-56, 2008

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