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Integration of biomass formulations of genome-scale metabolic models with experimental data reveals universally essential cofactors in prokaryotes

  • Metabolic Engineering, 39, 200-208, 2017

Publisher: Elsevier

Abstract

The composition of a cell in terms of macromolecular building blocks and other organic molecules underlies the metabolic needs and capabilities of a species. Although some core biomass components such as nucleic acids and proteins are evident for most species, the essentiality of the pool of other organic molecules, especially cofactors and prosthetic groups, is yet unclear. Here we integrate biomass compositions from 71 manually curated genome-scale models, 33 large-scale gene essentiality datasets, enzyme-cofactor association data and a vast array of publications, revealing universally essen ...

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