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A network perspective on antimicrobial peptide combination therapies: the potential of colistin, polymyxin B and nisin

  • International Journal of Antimicrobial Agents, 49(6), 668-676, 2017

Publisher: Elsevier

Abstract

Antimicrobial combinations involving antimicrobial peptides (AMPs) attract considerable attention within current antimicrobial and anti-resistance research. The objective of this study was to review the available scientific literature on the effects of antimicrobial combinations involving colistin (polymyxin E), polymyxin B and nisin, which are US Food and Drug Administration (FDA)-approved AMPs broadly tested against prominent multidrug-resistant pathogens. A bioinformatics approach based on literature mining and manual expert curation supported the reconstruction of experimental evidence on ...

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