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Optimization of fermentation conditions for the production of curcumin by engineered Escherichia coli

  • Journal of the Royal Society Interface, (Accepted), 2017

Publisher: The Royal Society

Abstract

Curcumin is a plant secondary metabolite with outstanding therapeutic effects. Therefore, there is a great interest in developing new strategies to produce this high-value compound in a cheaper and environmentally friendly way. Curcumin heterologous production in E. coli using artificial biosynthetic pathways was previously demonstrated using synthetic biology approaches. However, the culturing conditions to produce this compound were not optimized and so far only a two-step fermentation involving the exchange of the culture medium allowed to obtain high concentrations of curcumin, which limit ...

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