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Genome-scale modeling of yeast: chronology, applications and critical perspectives

  • FEMS Yeast Research, 17(5), fox050, 2017

Publisher: Oxford University Press

Abstract

Over the last 15 years, several genome-scale metabolic models (GSMMs) were developed for different yeast species, aiding both the elucidation of new biological processes and the shift toward a bio-based economy, through the design of in silico inspired cell factories. Here, an historical perspective of the GSMMs built over time for several yeast species is presented and the main inheritance patterns among the metabolic reconstructions are highlighted. We additionally provide a critical perspective on the overall genome-scale modeling procedure, underlining incomplete model validation and evalu ...

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