Publications in International Journals / Series (Article (International))

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells

  • Gonçalves, Emanuel; Sciacovelli, Marco; Costa, Ana S.H.; Tran, Maxine Gia Binh; Johnson, Timothy Isaac; Machado, Daniel; Frezza, Christian; Saez-Rodriguez, Julio
  • Metabolic Engineering, 45, 149-157, 2018

Publisher: Elsevier

Abstract

Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of their co-regulation are still largely unknown. Here we designed and acquired proteomics, phosphoproteomics, and metabolomics experiments in fumarate hydratase (FH) deficient cells and developed a computational modelling approach to identify putative regulatory phosphorylation-sites of metabolic enzymes. We identified previously reported functio ...

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