Publications in International Journals / Series (Review (International))

Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test

  • Metabolomics, 14(4), 43-43, 2018

Publisher: Springer Nature

Abstract

Introduction Microbial cells secrete many metabolites during growth, including important intermediates of the central carbon metabolism. This has not been taken into account by researchers when modeling microbial metabolism for metabolic engineering and systems biology studies. Materials and Methods The uptake of metabolites by microorganisms is well studied, but our knowledge of how and why they secrete different intracellular compounds is poor. The secretion of metabolites by microbial cells has traditionally been regarded as a consequence of intracellular metabolic overflow. Conclusions Her ...

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