Publications in International Journals / Series (Review (International))

Methods for automated genome-scale metabolic model reconstruction

  • Biochemical Society Transactions, 46(4), 931-936, 2018

Publisher: Portland Press, Ltd.


In the era of next-generation sequencing and ubiquitous assembly and binning of metagenomes, new putative genome sequences are being produced from isolate and microbiome samples at ever-increasing rates. Genome-scale metabolic models have enormous utility for supporting the analysis and predictive characterization of these genomes based on sequence data. As a result, tools for rapid automated reconstruction of metabolic models are becoming critically important for supporting the analysis of new genome sequences. Many tools and algorithms have now emerged to support rapid model reconstruction a ...

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