Publications in International Journals / Series (Article (International))

Mapping Salmonella typhimurium pathways using 13C Metabolic Flux Analysis

  • Metabolic Engineering, 52, 303-314, 2019

Publisher: Elsevier

Abstract

In the last years, Salmonella has been extensively studied not only due to its importance as a pathogen, but also as a host to produce pharmaceutical compounds. However, the full exploitation of Salmonella as a platform for bioproduct delivery has been hampered by the lack of information about its metabolism. Genome-scale metabolic models can be valuable tools to delineate metabolic engineering strategies as long as they closely represent the actual metabolism of the target organism. In the present study, a 13C-MFA approach was applied to map the fluxes at the central carbon pathways of S. typ ...

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