Publications in International Journals / Series (Article (International))

Metabolic models and gene essentiality data reveal essential and conserved metabolism in prokaryotes

  • PLoS Computational Biology, 14(11), 1-23, 2018

Publisher: Public Library of Science

Abstract

If we tried to list every known chemical reaction within an organism–human, plant or even bacteria–we would get quite a long and confusing read. But when this information is represented in so-called genome-scale metabolic networks, we have the means to access computationally each of those reactions and their interconnections. Some parts of the network have alternatives, while others are unique and therefore can be essential for growth. Here, we simulate growth and compare essential reactions and genes for the simplest type of unicellular species–prokaryotes–to understand which parts of their m ...

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