Publications in International Journals / Series (Article (International))

In silico prediction reveals the existence of potential bioactive neuropeptides produced by the human gut microbiota

  • Food Research International, 119, 221-226, 2019

Publisher: Elsevier

Abstract

This work reports on a large-scale potential neuropeptide activity screening in human gut microbiomes deposited in public databases. In our experimental approach, the sequences of the bioactive peptides collected in the MAHMI database, mainly predicted as immunomodulatory or antitumoral, were crossed with those of the neuroactive/digestive peptides. From 91,325,790 potential bioactive peptides, only 581 returned a match when crossed against the 5949 neuroactive peptides from the NeuroPep database and the 15 digestive hormones. Relevant bacterial taxa, such as Ruminococcus sp., Clostridium sp. ...

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