Publications in International Journals / Series (Article (International))

Computational prediction of the bioactivity potential of proteomes based on expert knowledge

  • Blanco-Míguez, Aitor; Blanco, Guillermo; Gutierrez-Jácome, Alberto; Fdez-Riverola, Florentino; Sánchez, Borja; Lourenço, Anália
  • JOURNAL OF BIOMEDICAL INFORMATICS, 91(103121), 2019

Publisher: Elsevier

Abstract

Advances in the field of genome sequencing have enabled a comprehensive analysis and annotation of the dynamics of the protein inventory of cells. This has been proven particularly rewarding for microbial cells, for which the majority of proteins are already accessible to analysis through automatic metagenome annotation. The large-scale in silico screening of proteomes and metaproteomes is key to uncover bioactivities of translational, clinical and biotechnological interest, and to help assign functions to certain proteins, such as those predicted as hypothetical. This work introduces a new me ...

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