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Turnover dependent phenotypic simulation: a quantitative constraint-based simulation method that accommodates all main strain design strategies

  • ACS Synthetic Biology, 8(5), 976-988, 2019

Publisher: American Chemical Society

Abstract

The uncertain relationship between genotype and phenotype can make strain engineering an arduous trial and error process. To identify promising gene targets faster, constraint-based modelling methodologies are often used, although they remain limited in their predictive power. Even though the search for gene knock-outs is fairly established in constraint-based modelling, most strain design methods still model gene up/down-regulations by forcing the corresponding flux values to fixed levels without taking in consideration the availability of resources. Here, we present a constraint-based algori ...

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