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Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli

  • Marani, Mariela M.; Perez, Luis O.; Araujo, Alyne Rodrigues de; Plácido, Alexandra; Sousa, Carla F.; Quelemes, Patrick Veras; Oliveira, Mayara; Gomes-Alves, Ana Georgina; Pueta, Mariana; Gameiro, Paula; Tomás, Ana M.; Delerue-Matos, Cristina; Eaton, Peter; Camperi, Silvia A.; Basso, Néstor G.; Leite, Jose Roberto de Souza de Almeida
  • Gene, 605, 70-80, 2017

Publisher: Elsevier

Abstract

Patagonia's biodiversity has been explored from many points of view, however, skin secretions of native amphibians have not been evaluated for antimicrobial peptide research until now. In this sense, Pleurodema thaul is the first amphibian specie to be studied from this large region of South America. Analysis of cDNA-encoding peptide in skin samples allowed identification of four new antimicrobial peptides. The predicted mature peptides were synthesized and all of them showed weak or null antimicrobial activity against Klebsiella pneumoniae, Staphylococcus aureus and Escherichia coli with the ...

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