Publications in International Journals / Series (Article (International))

Loading of 5-aminosalicylic in solid lipid microparticles (SLM): Solubility screening of lipid excipients and physicochemical characterization

  • Silveira, Elisânia F.; Rannier, Lucas; Nalone, Luciana; da Silva, Classius F.; Chaud, Marco V.; de M. Barbosa, Raquel; Junior, Ricardo L. C. A.; da Costa, Luiz P.; Souto, Eliana B.; Severino, Patrícia
  • Journal of Thermal Analysis and Calorimetry, (In Press), 2019

Publisher: Springer

Abstract

5-Aminosalicylic acid (5-ASA), the active moiety of sulphasalazine, is the most commonly used drug for treating patients with inflammatory bowel disease (IBD). Its bioavailability is low, i.e. 20--30\% upon oral administration and 10--35\\% by rectal administration. As the extent of 5-ASA absorption is very much dependent on the time-length, the drug is retained in the colon, a way to increase drug retention is the use of orally administered sustained released formulations. Solid lipid microparticles (SLM) are a viable option for site-specific targeted delivery in compressed tablets produced b ...

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