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Stability of clavulanic acid under variable pH, ionic strength and temperature conditions: a new kinetic approach
- Santos, V.C.; Pereira, J.F.B.; Haga, R.B.; Rangel-Yagui, C.O.; Teixeira, José A.; Converti, A.; Pessoa Júnior, A.
- Biochemical Engineering Journal, 45(2), 89-93, 2009
Publisher: Elsevier
Abstract
Clavulanic acid (CA) is a β-lactam antibiotic that alone exhibits only weak antibacterial activity, but is a potent inhibitor of β-lactamases enzymes. For this reason it is used as a therapeutic in conjunction with penicillins and cephalosporins. However, it is a well-known fact that it is unstable not only during its production phase, but also during downstream processing. Therefore, the main objective of this study was the evaluation of CA long-term stability under different conditions of pH and temperature, in the presence of variable levels of different salts, so as to suggest the best con ...
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