Publications in International Journals / Series (Article (International))
Development, in vitro release and in vivo bioavailability of sustained release nateglinide tablets
- Venkatesh, D.N.; Meyyanathan, S.N.; Shanmugam, R.; Zielinska, A.; Campos, J.R.; Ferreira, J.D.; Souto, Eliana B.
- Journal of Drug Delivery Science and Technology, 55(101355), 2020
Publisher: Elsevier
Abstract
Purpose The scope of this work is the characterization of the behavior of polysaccharides, such as xanthan gum, as matrix-forming agent for the development of sustained release tablets containing nateglinide. Methods Conventional immediate release (IR) and sustained release (SR) tablets were produced by wet granulation and direct compression methodologies, respectively. FTIR analysis demonstrated no interactions between drug and excipients, as the physicochemical characteristics of bulk materials were kept in the formulated tablets. Results Fresh IR and SR tablets exhibited appropriate friabil ...
CEB Authors
Groups
CEB is supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding UIDB/04469/2020.
2025 © CEB - Centre of Biological Engineering. All Rights Reserved.
