Publications in International Journals / Series (Article (International))
Encapsulated bacteriophages in alginate-nanohydroxyapatite hydrogel as a novel delivery system to prevent orthopedic implant-associated infections
- Barros, J.; Melo, Luís D.R.; Silva, R.A.; Ferraz, M.P.; Azeredo, Joana; Pinheiro, V.; Colaço, B.; Fernandes, M.H.; Gomes, P.S.; Monteiro, F.J.
- Nanomedicine-Nanotechnology Biology and Medicine, 24(102145), 2020
Publisher: Elsevier
Abstract
An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel was developed as a multifunctional approach for local tissue regeneration and infection prevention and control. Bacteriophages were efficiently encapsulated, without jeopardizing phage viability and functionality, nor affecting hydrogel morphology and chemical composition. Bacteriophage delivery occurred by swelling-disintegration-degradation process of the alginate structure and was influenced by environmental pH. Good tissue response was observed following the implantation of bacteriophages-load ...
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