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Quinoline- and benzoselenazole-derived unsymmetrical squaraine cyanine dyes: design, synthesis, photophysicochemical features and light-triggerable antiproliferative effects against breast cancer cell lines

  • Lima, Eurico; Boto, Renato E.; Ferreira, Diana; Fernandes, José R.; Almeida, Paulo; Ferreira, Luis F.V.; Souto, Eliana B.; Silva, Amélia M.; Reis, Lucinda V.

Publisher: MDPI Publishing

Abstract

Photodynamic therapy is an innovative treatment approach broadly directed towards oncological diseases. Its applicability and efficiency are closely related to the interaction of three main components, namely a photosensitizer, light and molecular triplet oxygen, which should drive cell death. Recently, several studies have demonstrated that squaraine cyanine dyes have a set of photophysical and photochemical properties that have made of these compounds’ potential photosensitizers for this therapeutic modality. In the present research work, we describe the synthesis and characterization ...

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