Publications in International Journals / Series (Review (International))
Natural ergot alkaloids in ocular pharmacotherapy: known molecules for novel nanoparticle-based delivery systems
- Baldim, Iara; Oliveira, Wanderley P.; Kadian, Varsha; Rao, Rekha; Yadav, Nitesh; Mahant, Sheefali; Lucarini, Massimo; Durazzo, Alessandra; Da Ana, Raquel; Capasso, Raffaele; Souto, Selma B.; Santini, Antonello; Souto, Eliana B.
- Biomolecules, 10(7), 980, 2020
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Abstract
Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery ...
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