Publications in International Journals / Series (Article (International))
Lipid-based nanostructures as a strategy to enhance curcumin bioaccessibility: behavior under digestion and cytotoxicity assessment
- Gonçalves, Raquel F.S.; Martins, Joana T.; Abrunhosa, Luís; Baixinho, João; Matias, Ana A.; Vicente, António A.; Pinheiro, Ana Cristina
- Food Research International, 143(110278), 2021
Publisher: Elsevier
Abstract
The aim of this study was to evaluate the behavior of different lipid-based nanostructures during in vitro digestion, in particular on curcumin’s bioaccessibility, and to access their potential toxicity. Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE) were submitted to harmonized static in vitro digestion and their cytotoxicity and cellular transport were evaluated using Caco-2 cell line. NE presented the highest curcumin’s bioaccessibility followed by NLC and SLN, 71.1%, 63.7% and 53.3%, respectively. Free fatty acids percentage increased in the fol ...
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