Conference Proceedings (Abstracts in Conference Proceedings)
Understanding the genome architecture and evolution of Shiga toxin encoding bacteriophages of Escherichia coli
- Pinto, Graça; Sampaio, Marta; Dias, Oscar; Almeida, Carina; Azeredo, Joana; Oliveira, Hugo
- BOD 2021 - X Bioinformatics Open Days. Braga, Portugal, May 05-08, 56, 2021
Abstract
Shiga toxin-producing Escherichia coli (STEC) is an important foodborne pathogen, and its major virulence factor is their ability to produce Shiga toxins. This toxin is coded by the stx gene, acquired through the insertion of a prophage into their genome. In our study, 179 STEC genomes were analysed for their serotype, distribution, and stx gene variants. Stx phages were also analysed and grouped based on shared gene content. We show that most STEC were isolated from different sources and geographical regions and belong to the non-O157 serotypes (73%). While the majority of STEC encode a singl ...
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