MSc Dissertations
A phage-based tool for targeting Aß species in Alzheimer’s disease and monitor disease progression / Reconhecimento de espécies de Aβ na doença de Alzheimer e monitorização da progressão da doença através de uma ferramenta baseada em fagos
- Lima, Alexandre [Supervisors: Martins, Ivone M.]
- Mestrado em Biotecnologia, 2021
Abstract
Currently, 55 million people live with dementia worldwide, and this number is estimated to increase more than threefold (~139 million) by 2050. Alzheimer’s disease, one of the most prominent types of dementia, characterizes by the increased deposition of extracellular insoluble plaques composed of amyloid-beta peptide. Recent studies demonstrate that small and soluble amyloid-beta oligomers are sufficient to impair synaptic function and represent the major toxic agents. For this reason, different assembles of amyloid-beta have been considered as important biomarkers for the diagnosis and thera ...
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